13th Rembrandt Symposium 18-11-2022
Click on the “abstract title” to view the abstract.
| Registration
Nord Boulevard |
| Plenary Session 1
Sorbonne 2 |
| Introduction & opening Presenters: Prof. Paul Quax & prof. Jaap van Buul |
| Keynote 1: prof. dr. Patrick Rensen (Leiden UMC) Targeting energy expenditure to combat cardiometabolic diseases Chair: dr. Jan Willem Buikema |
| Oral plenary session Chairs: prof. Patrick Rensen & dr. Jan Willem Buikema |
| 69 Kim Dzobo
Lipoprotein(a) increases intraplaque angiogenesis in carotid endarterectomy plaques via the upregulation of VEGFA
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| 47 Ruben Methorst
Using Mendelian randomization to explore sex differences in pain manifestation of coronary artery disease
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| 71 Sebastiaan Laan
Phenotypic heterogeneity within healthy donor endothelial colony forming cells explored by morphological analysis and RNA expression profiling.
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| 12 Merve Bulut
Engineered 3D vessels-on-chip to model inflammatory responses using hiPSC-derived vascular cells and monocytes |
| 60 Ricky Siebeler
The histone demethylase KDM3A modulates macrophage pro-inflammatory phenotype in atherosclerosis |
| 54 Ralph Neijenhuis
The potential of Sodium-Glucose Cotransporter 2 Inhibitors in the Treatment of Heart Failure in Adults with Congenital Heart Disease |
| Coffee break (North Boulevard) |
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Blitz parallel sessions
Session 1: Atherosclerosis
Oxford 18 Chairs: dr. Ilze Bot & dr. Aldo Grefhorst |
| 1 Milena Schönke
Exercise mimetic IC7Fc outperforms atorvastatin in reducing atherosclerosis and lowers plasma lipids through inhibition of VLDL production
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| 5 Lushun Yuan
Sex-specific association between microvascular health and coagulation parameters: the Netherlands Epidemiology of Obesity (NEO) Study |
| 6 Xiaoke Ge
Pharmacological DHCR24 inhibition to increase desmosterol reduces circulating leukocytes without inducing hyperlipidemia
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| 39 Winnie Vos
Targeting CBL-B in atherosclerosis: putting the brake on inflammation |
| 11 Robin van Eenige
Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3- Leiden,CETP mice |
| 22 Tamar Woudenberg
Endothelial integrity in intracranial atherosclerosis; the regulatory role of N6- methyladenosine (m6A) of the pro-atherogenic microRNA miR-494-3p in tight junction proteins |
| 27 Maaike de Jong
Antigen specific CD4+ T-cells control CD8+ T-cell expansion in the atherosclerotic lesion
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| 29 Marie Depuydt
Single-cell T cell Receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells
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| 31 Fernando Lozano Vigario
Immunopeptidomic analysis of human atherosclerosis plaques for identification of antigenic drivers of atherosclerosis
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| 7 Cong Liu
Choline and butyrate beneficially modulate the gut microbiome without affecting atherosclerosis in APOE*3-Leiden,CETP mice
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| 52 Rosalie Kempkes
Targeting EZH2 shifts macrophages towards a less inflammatory phenotype in atherosclerosis
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| 53 Lucie Delfos
Systemic mast cell activation does not affect atherosclerotic lesion development in the absence of T- and B cells
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| 34 Koen Prange
Taming the macrophage: novel players in inflammatory activation
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| 33 Rosalie Rietjens
Phosphatidylinositol metabolism of the proximal tubule S3 segment is disturbed in early diabetic nephropathy
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| 8 Zhixiong Ying
Mirabegron activates thermogenic tissues to increase atherosclerosis only in absence of a functional hepatic ApoE-LDLR pathway
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| 45 Diederick Verheijen
Neo-aortic dimensions and coronary take-off angle in adolescent and young adult patients after arterial switch operation due to transposition of the great arteries |
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Blitz parallel sessions
Session 2: Vascular Biology & Homeostasis Sorbonne 2
Chairs: dr. Jesper Hjortnaes & prof. Jaap van Buul |
| 18 Job Schippers
Efficacy and Safety of Intravenous Imatinib in COVID-19 ARDS: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial
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| 24 Erik Bakker
Perivascular clearance of blood proteins after blood-brain barrier disruption in a rat model of micro-infarcts
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| 26 Loïs van der Pluijm
SGLT2 inhibition promotes intrinsic kidney regeneration by cells of the renin lineage |
| 38 Dejvid Veizaj
Combined Molecular Dynamics and AlphaFold2 Studies on Direct Oral Anticoagulant Binding to Factor Xa Variants
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| 58 Sabine van der Horst
Prevalence and Predictors of Non-Adherence to Direct Oral Anticoagulant Treatment in Patients with Atrial Fibrillation, a Historical Cohort Study |
| 40 Clarissa Becher
BMP-9 protects from IL-33 induced endothelial-to-mesenchymal transition in Pulmonary Arterial Endothelial Cells
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| 42 Suzanne Laboyrie
Mice with Autosomal Dominant Polycystic Kidney Disease (ADPKD) have increased arteriovenous fistula functionality |
| 55 Wendy Stam
Maternal anti-integrin β3 antibodies derived from fetal/neonatal alloimmune thrombocytopenia (FNAIT) cases target endothelial cells and cause defects in angiogenesis |
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| 68 Rudmer Postma
Novel morphological profiling assay to study the role of endothelial cells in the disease trajectory of liver cirrhosis in vitro
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| 16 Noa Linthorst
Allele-selective inhibition of mutant von Willebrand factor with small interfering RNAs in a von Willebrand disease mouse model
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| 35 Arnout Mieremet
Phenotypic screening in Marfan syndrome patient-derived cells reveals drug candidates normalizing reduced nuclear KLF4 expression
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| 36 Maxime Cammeraat
Live-cell labeling and imaging of dynamic processes in endothelial cell migration and sprouting angiogenesis |
| 61 Dieuwke Luijten
A randomized controlled trial to evaluate the efficacy and safety of an 8-week homebased standardized exercise training program for preventing post-pulmonary embolism syndrome: rationale and design of the PE@HOME study |
| 62 Cindy de Jong
Cost-effectiveness of performing reference ultrasonography in patients with deep vein thrombosis
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| 63 Emily Martens
Risk of venous thromboembolism and major bleeding in the clinical course of osteosarcoma and Ewing sarcoma
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| 74 Rianne Schoon
Identification of novel VE-cadherin binding proteins that regulate the endothelial barrier |
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Blitz parallel sessions Session 3: Metabolism & Cardiac Diseases Oxford 20 Chairs: dr. Sander Kooijman & dr. Frances Handoko-de Man
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| 57 Tamara Borsboom
Vascular Outflow Tract Development: Fate mapping the Arterial Epicardium in the Ascending Aorta
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| 32 Caroline Pham
TNNI3K delays atrioventricular conduction and reduces connexin-45 gap junctional coupling
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| 3 Qiao Zhao
Circulating yRNAs and their fragments as potential biomarkers for diabetic nephropathy
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| 21 Yang Xiao
Glycolytic Dependence of Cardioprotection by Nicotinamide Riboside |
| 25 Sha Chen
SGLT2 inhibitor Empagliflozin reduces infarct size independent of SGLT2
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| 28 Elizaveta Polyakova
Genetic variant in the MYH7 gene in a patient with a hypoplastic right heart syndrome: a case report and literature overview,
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| 30 Simona Casini
Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes
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| 50 Lieke van Roon
Acute myocardial infarction induces remodeling of the murine superior cervical ganglia and the carotid body
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| 2 Olga Papazisi
Diminished vasoresponsiveness in patients with heart failure is α1 receptor mediated: an in- and ex-vivo study
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| 66 Jose Inia
Repeated weight cycling in obese mice improves hepatic inflammation
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| 72 Marieke Nederend
Beneficial effects of treatment with sacubitril/valsartan in systemic right ventricular failure in adults with congenital heart disease lasting for up to 36 months
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| 9 Michiel Blok
Identification of novel epicardial paracrine factors involved in axon guidance and growth signaling
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| 51 Qianliang Yuan
Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC- Derived Cardiomyocytes
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| 19 Carmen Yap
Marfan mice fed on high fat diet have an altered metabolism |
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| Plenary Session 2
Sorbonne 2 |
| Keynote 2: Prof. dr. Folkert Asselbergs (Amsterdam UMC) AI in Cardiology: hype, hope or phobia? Chair: prof. Marie-José Goumans |
| Rembrandt Project Reports 2018 Chairs: prof. Anton Jan van Zonneveld & prof. Jaap van Buul |
| Novella Nicese
Diabetic nephropathy, gut microbiota and its metabolites: understanding their interplay with in vitro and in vivo models
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| Lot Mosterd
Plasma and urine metabolites in patients with CKD and/or type 2 diabetes: focus on different ethnicities
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| Coffee break
North Boulevard |
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| Oral parallel sessions
Session 1: Atherosclerosis
Oxford 18 |
| 44 Jamie Kane
Chronic kidney disease and peritoneal dialysis induce a pro-inflammatory atherogenic phenotype in mice
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| 48 Nathalie Reilly
Quiescent CD4+ T cells exposed to oleic acid upregulate genes involved in immunometabolism resulting in increased IL-9+ frequencies post-activation
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| 49 Esmeralda Hemme
Leukemia inhibitory factor receptor inhibition in atherosclerosis
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| 59 Bram van Os
Hyperlipidemia elicits an atypical, Th1 like CD4+ T cell response: a key role for VLDL |
| 65 Jill de Mol
An aged immune system accelerates atherosclerosis development in mice
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| 70 Wieke Grievink
Cardiovascular risk factors: the effects of ageing and smoking on the immune system, an observational clinical study
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| 64 Virginia Smit
Single-cell profiling of age-associated immunity in murine atherosclerosis |
| Oral parallel sessions
Session 2: Vascular Biology & Metabolism
Sorbonne 2 |
| 14 Vincent Sier
Inhibition of ALK2/3 signaling reduces vein graft wall thickening via pro-inflammatory cytokine expression in macrophages
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| 17 Ulgu Arslan
Vascularized hiPSC-derived 3D cardiac microtissue on chip
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| 23 Gonzalo Sanchez-Duffhues
Endothelial to mesenchymal transition (EndoMT) of preeclamptic feto-placental endothelial cells (PE fpEC) is governed by BMP signaling
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| 13 Carlijn Hoekx
Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue
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| 15 Erik Duijvelaar
Imatinib treatment improves glucose metabolism in patients with COVID-19
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| 67 José Inia
Semaglutide has beneficial effects on non-alcoholic steatohepatitis in LDLr-/-,Leiden mice
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| 37 Marijn Peters
Lentiviral Vectors can Deliver Immune Evasive Genes into Human Homograft Heart Valves: A Study of Viral Penetration |
| Oral parallel sessions
Session 3: Cardiac Diseases & Arhythmias
Oxford 20 |
| 4 Alessandra Lodrini
Developing regenerative therapies targeting cardiomyocytes using organotypic slice culture from human adult ventricular myocardium |
| 20 Hoi Wai Wu
Mutation in PDGFRβ gene: a potential new pathogenic variant for mitral valve prolapse
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| 73 Marieke Nederend
Single-centre experience in veno-venous collaterals and coiling in adult congenital heart disease patients with univentricular physiology after Fontan palliation
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| 10 Lieve van der Maarel
Disruption of a long-range regulatory mechanism on Ch4q25 underlies sinoatrial node dysfunction and induces ectopic Pitx2 expression in the sinoatrial node
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| 41 Madelief Marsman
Heat-induced conduction acceleration in sodium channel haploinsufficient mice
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| 43 Jaël Copier
Recurrent variant of unknown significance in KCNH2 classified through functional characterisation
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| 46 Diederick Verheijen
Invasive evaluation in asymptomatic adult patients with a right AAOCA with high-risk anatomy |
| Small break to walk to Sorbonne 2 |
| Plenary Session 3
Sorbonne 2 |
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| Best Presentation Award
Presenters: organizing committee
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| Rembrandt Grant 2022
Presenter: prof. Paul Quax |
| Closing remarks Presenters: prof. Paul Quax & prof. Jaap van Buul |
| Borrel & Drinks
North Boulevard |
