Program 13th Rembrandt Symposium

REMBRANDT INSTITUTE OF CARDIOVASCULAR SCIENCE

13th Rembrandt Symposium 18-11-2022

Click on the “abstract title” to view the abstract.

09:00-09:30

Registration
Nord Boulevard

09:30-11:00

Plenary Session 1
Sorbonne 2

09:30-09:35

Introduction & opening

Presenters: Prof. Paul Quax & prof. Jaap van Buul

09:35-10:00

Keynote 1: prof. dr. Patrick Rensen (Leiden UMC)

Targeting energy expenditure to combat cardiometabolic diseases

Chair: dr. Jan Willem Buikema

10:00-11:00 

Oral plenary session

Chairs: prof. Patrick Rensen & dr. Jan Willem Buikema

10:00-10:10

69 Kim Dzobo
Lipoprotein(a) increases intraplaque angiogenesis in carotid endarterectomy plaques via the upregulation of VEGFA

10:10-10:20

47 Ruben Methorst
Using Mendelian randomization to explore sex differences in pain manifestation of coronary artery disease

10:20-10:30

71 Sebastiaan Laan
Phenotypic heterogeneity within healthy donor endothelial colony forming cells explored by morphological analysis and RNA expression profiling.

10:30-10:40

12 Merve Bulut
Engineered 3D vessels-on-chip to model inflammatory responses using hiPSC-derived vascular cells and monocytes

10:40-10:50

60 Ricky Siebeler
The histone demethylase KDM3A modulates macrophage pro-inflammatory phenotype in atherosclerosis

10:50-11:00

54 Ralph Neijenhuis
The potential of Sodium-Glucose Cotransporter 2 Inhibitors in the Treatment of Heart Failure in Adults with Congenital Heart Disease

11:00-11:30

Coffee break (North Boulevard)

11:30-12:10


Blitz parallel sessions
Session 1: Atherosclerosis
Oxford 18

Chairs: dr. Ilze Bot & dr. Aldo Grefhorst

11:30–11:35

1 Milena Schönke
Exercise mimetic IC7Fc outperforms atorvastatin in reducing atherosclerosis and lowers plasma lipids through inhibition of VLDL production

11:35-11:40

5 Lushun Yuan
Sex-specific association between microvascular health and coagulation parameters: the Netherlands Epidemiology of Obesity (NEO) Study

11:40-11:45

6 Xiaoke Ge
Pharmacological DHCR24 inhibition to increase desmosterol reduces circulating leukocytes without inducing hyperlipidemia

11:45-11:50

39 Winnie Vos
Targeting CBL-B in atherosclerosis: putting the brake on inflammation

11:50-11:55

11 Robin van Eenige
Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3- Leiden,CETP mice

11:55-12:00

22 Tamar Woudenberg
Endothelial integrity in intracranial atherosclerosis; the regulatory role of N6- methyladenosine (m6A) of the pro-atherogenic microRNA miR-494-3p in tight junction proteins

12:00-12:05

27 Maaike de Jong
Antigen specific CD4+ T-cells control CD8+ T-cell expansion in the atherosclerotic lesion

12:05-12:10

29 Marie Depuydt
Single-cell T cell Receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells

12:10-12:20

Break

12:20-12:25

31 Fernando Lozano Vigario
Immunopeptidomic analysis of human atherosclerosis plaques for identification of antigenic drivers of atherosclerosis

12:25-12:30

7 Cong Liu
Choline and butyrate beneficially modulate the gut microbiome without affecting atherosclerosis in APOE*3-Leiden,CETP mice

12:30-12:35

52 Rosalie Kempkes
Targeting EZH2 shifts macrophages towards a less inflammatory phenotype in atherosclerosis

12:35-12:40

53 Lucie Delfos
Systemic mast cell activation does not affect atherosclerotic lesion development in the absence of T- and B cells

12:40-12:45

34 Koen Prange
Taming the macrophage: novel players in inflammatory activation

12:45-12:50

33 Rosalie Rietjens
Phosphatidylinositol metabolism of the proximal tubule S3 segment is disturbed in early diabetic nephropathy

12:50-12:55

8 Zhixiong Ying
Mirabegron activates thermogenic tissues to increase atherosclerosis only in absence of a functional hepatic ApoE-LDLR pathway

12:55-13:00

45 Diederick Verheijen
Neo-aortic dimensions and coronary take-off angle in adolescent and young adult patients after arterial switch operation due to transposition of the great arteries

11:30-12:10


Blitz parallel sessions
Session 2: Vascular Biology & Homeostasis

Sorbonne 2

Chairs: dr. Jesper Hjortnaes & prof. Jaap van Buul

11:30–11:35

18 Job Schippers
Efficacy and Safety of Intravenous Imatinib in COVID-19 ARDS: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial

11:35-11:40

24 Erik Bakker
Perivascular clearance of blood proteins after blood-brain barrier disruption in a rat model of micro-infarcts

11:40-11:45

26 Loïs van der Pluijm
SGLT2 inhibition promotes intrinsic kidney regeneration by cells of the renin lineage

11:45-11:50

38 Dejvid Veizaj
Combined Molecular Dynamics and AlphaFold2 Studies on Direct Oral Anticoagulant Binding to Factor Xa Variants

11:50-11:55

58 Sabine van der Horst
Prevalence and Predictors of Non-Adherence to Direct Oral Anticoagulant Treatment in Patients with Atrial Fibrillation, a Historical Cohort Study

11:55-12:00

40 Clarissa Becher
BMP-9 protects from IL-33 induced endothelial-to-mesenchymal transition in Pulmonary Arterial Endothelial Cells

12:00-12:05

42 Suzanne Laboyrie
Mice with Autosomal Dominant Polycystic Kidney Disease (ADPKD) have increased arteriovenous fistula functionality

12:05-12:10

55 Wendy Stam
Maternal anti-integrin β3 antibodies derived from fetal/neonatal alloimmune thrombocytopenia (FNAIT) cases target endothelial cells and cause defects in angiogenesis

12:10-12:20

Break

12:20-12:25

68 Rudmer Postma
Novel morphological profiling assay to study the role of endothelial cells in the disease trajectory of liver cirrhosis in vitro

12:25-12:30

16 Noa Linthorst
Allele-selective inhibition of mutant von Willebrand factor with small interfering RNAs in a von Willebrand disease mouse model

12:30-12:35

35 Arnout Mieremet
Phenotypic screening in Marfan syndrome patient-derived cells reveals drug candidates normalizing reduced nuclear KLF4 expression

12:35-12:40

36 Maxime Cammeraat
Live-cell labeling and imaging of dynamic processes in endothelial cell migration and sprouting angiogenesis

12:40-12:45

61 Dieuwke Luijten
A randomized controlled trial to evaluate the efficacy and safety of an 8-week homebased standardized exercise training program for preventing post-pulmonary embolism syndrome: rationale and design of the PE@HOME study

12:45-12:50

62 Cindy de Jong
Cost-effectiveness of performing reference ultrasonography in patients with deep vein thrombosis

12:50-12:55

63 Emily Martens
Risk of venous thromboembolism and major bleeding in the clinical course of osteosarcoma and Ewing sarcoma

12:55-13:00

74 Rianne Schoon
Identification of novel VE-cadherin binding proteins that regulate the endothelial barrier

11:30-12:10


Blitz parallel sessions

Session 3: Metabolism & Cardiac Diseases

Oxford 20

Chairs: dr. Sander Kooijman & dr. Frances Handoko-de Man

11:30–11:35

57 Tamara Borsboom
Vascular Outflow Tract Development: Fate mapping the Arterial Epicardium in the Ascending Aorta

11:35-11:40

32 Caroline Pham
TNNI3K delays atrioventricular conduction and reduces connexin-45 gap junctional coupling

11:40-11:45

3 Qiao Zhao
Circulating yRNAs and their fragments as potential biomarkers for diabetic nephropathy

11:45-11:50

21 Yang Xiao
Glycolytic Dependence of Cardioprotection by Nicotinamide Riboside

11:50-11:55

25 Sha Chen
SGLT2 inhibitor Empagliflozin reduces infarct size independent of SGLT2

11:55-12:00

28 Elizaveta Polyakova
Genetic variant in the MYH7 gene in a patient with a hypoplastic right heart syndrome: a case report and literature overview,

12:00-12:05

30 Simona Casini
Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes

12:05-12:10

50 Lieke van Roon
Acute myocardial infarction induces remodeling of the murine superior cervical ganglia and the carotid body

12:10-12:20

Break

12:20-12:25

2 Olga Papazisi
Diminished vasoresponsiveness in patients with heart failure is α1 receptor mediated: an in- and ex-vivo study

12:25-12:30

66 Jose Inia
Repeated weight cycling in obese mice improves hepatic inflammation

12:30-12:35

72 Marieke Nederend
Beneficial effects of treatment with sacubitril/valsartan in systemic right ventricular failure in adults with congenital heart disease lasting for up to 36 months

12:35-12:40

9 Michiel Blok
Identification of novel epicardial paracrine factors involved in axon guidance and growth signaling

12:40-12:45

51 Qianliang Yuan
Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC- Derived Cardiomyocytes

12:45-12:50

19 Carmen Yap
Marfan mice fed on high fat diet have an altered metabolism

13:00-14:00

Lunch

North Beach

14:00-15:15

Plenary Session 2
Sorbonne 2

14:00-14:30

Keynote 2:

Prof. dr. Folkert Asselbergs (Amsterdam UMC)

AI in Cardiology: hype, hope or phobia?

Chair: prof. Marie-José Goumans

14:30-15:00

Rembrandt Project Reports 2018

Chairs: prof. Anton Jan van Zonneveld & prof. Jaap van Buul

14:30-14:45

Novella Nicese
Diabetic nephropathy, gut microbiota and its metabolites: understanding their interplay with in vitro and in vivo models

14:45-15:00

Lot Mosterd
Plasma and urine metabolites in patients with CKD and/or type 2 diabetes: focus on different ethnicities

15:00-15:30

Coffee break
North Boulevard

15:30-16:40

Oral parallel sessions

15:30-16:40

Oral parallel sessions
Session 1: Atherosclerosis
Oxford 18

15:30-15:40

44 Jamie Kane
Chronic kidney disease and peritoneal dialysis induce a pro-inflammatory atherogenic phenotype in mice

15:40-15:50

48 Nathalie Reilly
Quiescent CD4+ T cells exposed to oleic acid upregulate genes involved in immunometabolism resulting in increased IL-9+ frequencies post-activation

15:50-16:00

49 Esmeralda Hemme
Leukemia inhibitory factor receptor inhibition in atherosclerosis

16:00-16:10

59 Bram van Os
Hyperlipidemia elicits an atypical, Th1 like CD4+ T cell response: a key role for VLDL

16:10-16:20

65 Jill de Mol
An aged immune system accelerates atherosclerosis development in mice

16:20-16:30

70 Wieke Grievink
Cardiovascular risk factors: the effects of ageing and smoking on the immune system, an observational clinical study

16:30-16:40

64 Virginia Smit
Single-cell profiling of age-associated immunity in murine atherosclerosis

15:30-16:40

Oral parallel sessions
Session 2: Vascular Biology & Metabolism
Sorbonne 2

15:30-15:40

14 Vincent Sier
Inhibition of ALK2/3 signaling reduces vein graft wall thickening via pro-inflammatory cytokine expression in macrophages

15:40-15:50

17 Ulgu Arslan
Vascularized hiPSC-derived 3D cardiac microtissue on chip

15:50-16:00

23 Gonzalo Sanchez-Duffhues
Endothelial to mesenchymal transition (EndoMT) of preeclamptic feto-placental endothelial cells (PE fpEC) is governed by BMP signaling

16:00-16:10

13 Carlijn Hoekx
Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue

16:10-16:20

15 Erik Duijvelaar
Imatinib treatment improves glucose metabolism in patients with COVID-19

16:20-16:30

67 José Inia
Semaglutide has beneficial effects on non-alcoholic steatohepatitis in LDLr-/-,Leiden mice

16:30-16:40

37 Marijn Peters
Lentiviral Vectors can Deliver Immune Evasive Genes into Human Homograft Heart Valves: A Study of Viral Penetration

15:30-16:40

Oral parallel sessions
Session 3: Cardiac Diseases & Arhythmias
Oxford 20

15:30-15:40

4 Alessandra Lodrini
Developing regenerative therapies targeting cardiomyocytes using organotypic slice culture from human adult ventricular myocardium

15:40-15:50

20 Hoi Wai Wu
Mutation in PDGFRβ gene: a potential new pathogenic variant for mitral valve prolapse

15:50-16:00

73 Marieke Nederend
Single-centre experience in veno-venous collaterals and coiling in adult congenital heart disease patients with univentricular physiology after Fontan palliation

16:00-16:10

10 Lieve van der Maarel
Disruption of a long-range regulatory mechanism on Ch4q25 underlies sinoatrial node dysfunction and induces ectopic Pitx2 expression in the sinoatrial node

16:10-16:20

41 Madelief Marsman
Heat-induced conduction acceleration in sodium channel haploinsufficient mice

16:20-16:30

43 Jaël Copier
Recurrent variant of unknown significance in KCNH2 classified through functional characterisation

16:30-16:40

46 Diederick Verheijen
Invasive evaluation in asymptomatic adult patients with a right AAOCA with high-risk anatomy

16:40-16:50

Small break to walk to Sorbonne 2

16:50-17:20

Plenary Session 3
Sorbonne 2

16:50-16:55

HeART in Science Awards

16:55-17:10

Best Presentation Award
Presenters: organizing committee

17:10 -17:15

Rembrandt Grant 2022

Presenter: prof. Paul Quax

17:15-17:20

Closing remarks

Presenters: prof. Paul Quax & prof. Jaap van Buul

17:20-18:30

Borrel & Drinks
North Boulevard